蛋白质/抗原/多肽 >> 重组蛋白
重组ATP依赖的干扰素反应蛋白1
产品介绍 基因名: Tor3a 产品别名: Adir; Tor3a; torsin family 3, member A; torsin family 3, member A; torsin-3A; ATP-dependant interferon responsive; ATP-dependent interferon-responsive protein; ATP依赖的干扰素反应蛋白1; 耐扭蛋白3A(TOR3A); 背景信息: Torsin3A is a 397 amino acid member of the clpA/clpB family of proteins. Localized to the cytoplasm and the endoplasmic reticulum, Torsin3A is most highly expressed in stomach, lymph nodes and salivary glands. Torsin3A contains a hydrophobic N-terminal sequence, an ATP binding domain and 8 putative phosphorylation sites. Highly homologous with TorsinA and TorsinB, Torsin3A is thought to be related to the AAA chaperone-like family of ATPases. Members of this family play a role in the assembly, disassembly and operation of a variety of protein complexes, confer increased tolerance to high temperature and promote specific proteolysis. Torsin3A is also referred to as an interferon responsive gene, as interaction with type 1 interferons (IFN-alpha and IFN-beta) cause a 5 to 40 fold increase in Torsin3A mRNA levels. Three isoforms of Torsin3A exist as a result of alternative splicing events, and isoform 2 is expressed exclusively in the placenta 标签:His-tag |
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