蛋白质/抗原/多肽 >> 重组蛋白
重组RAGEF2蛋白
产品介绍 基因名: RAPGEF6 产品别名: KIA001LB; PDZ-GEF2; PDZGEF2; RA-GEF-2; RAGEF2; RAPGEF6; Rap guanine nucleotide exchange factor 6; Rap guanine nucleotide exchange factor 6; rap guanine nucleotide exchange factor 6; PDZ domain containing guanine nucleotide exchange factor (GEF) 2; PDZ domain-containing guanine nucleotide exchange factor 2; PDZ domain-containing guanine nucleotide exchange factor I; Rap guanine nucleotide exchange factor (GEF) 6; RAGEF2蛋白; 背景信息: RAPGEF6 is a guanine nucleotide exchange factor (GEF) that is expressed in a variety of tissues. Localizing to the cytoplasm and translocated to the plasma membrane upon ligand binding, RAPGEF6 contains an N-terminal Ras-GEF domain, a cyclic nucleotide monophosphate-binding domain, a PDZ (PSD-95/DlgA/ZO-1) domain, a Ras-associating (RA) domain and a Ras exchanger motif. RAPGEF6 is closely related to RAPGEF2 and both proteins exhibit GEF activity specific towards Rap 1 and Rap 2. In addition, RAPGEF6 is capable of binding to M-Ras via its RA domain. Due to alternative splicing events, two additional isoforms exist for RAPGEF6, namely PDZ-GEF2A and PDZ-GEF2B. 标签:His-tag |
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