蛋白质/抗原/多肽 >> 重组蛋白
重组雄激素受体复合物相关蛋白/核受体
产品介绍 基因名: DCAF6 产品别名: 1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP; PC326; DCAF6; DDB1 and CUL4 associated factor 6; DDB1 and CUL4 associated factor 6; DDB1- and CUL4-associated factor 6; IQ motif and WD repeat-containing protein 1; IQ motif and WD repeats 1; androgen receptor complex-associated protein; nuclear receptor interaction protein; 雄激素受体复合物相关蛋白/核受体; 背景信息: WD-repeat proteins are a large family of eukaryotic proteins coordinating multi-protein complex assemblies. Their role has been implicated in multiple cellular processes including signal transduction, transcriptional regulation, cell cycle control and apoptosis. NRIP is a novel 860a.a nuclear protein consisting of seven conserved WD40 domains and one NLS motif. It binds to androgen and glucocorticoid receptors and up-regulates their transcriptional activity, thereby functioning as a nuclear receptor co-activator. Role of NRIP has been implicated in cell growth and also in cervical and prostrate cancer, thus indicating a potential therapeutic intervention. Northern Blot analysis detects a high expression of NRIP in skeletal muscle and testis and low expression in heart, prostrate and adrenal gland. 标签:His-tag |
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