蛋白质/抗原/多肽 >> 重组蛋白
重组N-甲基-D-天氡氨酸离子能谷氨酸受体3B(GRIN3B)蛋白
产品介绍 基因名: GRIN3B 产品别名: GluN3B; NR3B; GRIN3B; glutamate ionotropic receptor NMDA type subunit 3B; glutamate ionotropic receptor NMDA type subunit 3B; glutamate receptor ionotropic, NMDA 3B; N-methyl-D-aspartate receptor subtype 3B; NMDA receptor subunit 3B; NMDA type glutamate receptor subunit NR3B; NMDAR3B; glutamate [NMDA] receptor subunit 3B; glutamate receptor, ionotropic, N-methyl-D-aspartate 3B; N-甲基-D-天氡氨酸离子能谷氨酸受体3B(GRIN3B); 谷氨酸受体3A; 谷氨酸受体3B; 背景信息: Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neuro-degeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. Kainate/AMPA receptors co-localize with NMDA receptors in many synapses and consist of seven structurally related subunits designated GluR-1 to 7. The kainate/AMPA receptors are primarily responsible for fast excitatory neurotransmission by glutamate, whereas the NMDA receptors exhibit slow kinesis of Ca2+ ions and a high permeability for Ca2+ ions. One such NMDA receptor, NR3B, is expressed in motor neurons and forms cation channels impermeable to calcium, which can resist many open-channel blockers. NR3B functions in the brain as an excitatory glycine receptor, modifying the normal role of glycine as an inhibitory neurotransmitter. 标签:His-tag |
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