蛋白质/抗原/多肽 >> 重组蛋白
重组PLEKHA7蛋白
产品介绍 基因名: PLEKHA7 产品别名: PLEKHA7; pleckstrin homology domain containing A7; pleckstrin homology domain containing A7; pleckstrin homology domain-containing family A member 7; PH domain-containing family A member 7; pleckstrin homology domain containing, family A member 2; pleckstrin homology domain containing, family A member 7; pleckstrin homology domain-containing family A member 6; PLEKHA7蛋白; 背景信息: PLEKHA7 (pleckstrin homology domain containing, family A member 7), also known as PH domain-containing family A member 7, is a 1,121 amino acid protein that contains one PH domain and two WW domains. Encoded by a gene that maps to human chromosome 11p15.1, PLEKHA7 exists as three alternatively spliced isoforms. Localizing to cell-cell junctions in Caco2 cells, PLEKHA7 interacts with the adherens junction protein p120 in human colon carcinoma cells. PLEKHA7 also colocalizes with zona adherens proteins and is necessary for zonula adherens biogenesis and maintenance. Associated with systolic blood pressure (SBP) and hypertension, PLEKHA7 is a potential target for the prevention or treatment of hypertension. PLEKHA7 is also linked to autoimmune hepatitis type 1, a chronic active hepatitis characterized by hypergammaglobulinemia and autoantibodies. 标签:His-tag |
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