蛋白质/抗原/多肽 >> 重组蛋白
重组信号调节蛋白β2/SIRP-β2
产品介绍 基因名: SIRPB2 产品别名: PTPN1L; PTPNS1L3; dJ776F14.2; SIRPB2; signal regulatory protein beta 2; signal regulatory protein beta 2; signal-regulatory protein beta-2; SIRP-beta-2; protein tyrosine phosphatase non-receptor type substrate protein; protein tyrosine phosphatase, non-receptor type substrate 1-like 3; 信号调节蛋白β2/SIRP-β2; 背景信息: Signal-regulatory protein beta-2(SIRP-beta-2), is a monomeric single pass type I membrane glycoprotein, belongs to the SIRP/SHPS (CD172) family of the immunoglobulin (Ig) superfamily. The SIRP family are paired receptors that have similar extracellular domains but differing C-terminal domains and functions. A positively charged residue within the transmembrane domain, in analogy to SIRP-beta-1, is implicated to mediate interaction with the adaptor DAP12 protein, which contains immunoreceptor tyrosine-based activation motifs (ITAMs) . Proteins in the SIRP family are typically expressed in immune cells, especially in the myeloid lineages . Based on expression patterns, SIRPs are thought to have roles in immune regulation. SIRP family members role in innate immunity and host defense has potential significance as a therapeutic target in cancer and inflammation. There are currently no known mouse or rat homologs for this protein. 标签:His-tag |
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